In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.
How do you feel about the use of Novasone Lotion % used daily by a female under the fingernails? My wife has a fungal infection (rather like “barmaids rot”) under her nails and has been prescribed the above lotion to use for about six months.
Nothing previously prescribed has been successful and I am a little concerned about corticosteroids being prescribed (by a skin specialist) for such a long period.
If you are in favour of its use, what important precautions should be adhered to and what must she avoid doing or what should she do?
No. with Atopic Dermatitis
No. with Psoriasis vulgaris
Mean age (years)
43 (range 22-57)
Mean duration of treatment with Group III or IV topical steroids (years)
16 (range 6-25)
Localization of skin atrophy:
Clinical evaluation of severity of symptoms and signs of skin atrophy at baseline and at end of treatment.
Clinical parameters Mean severity at baseline Mean severity at end of treatment Decreased thickness of skin (range 2-3) Laxity (range 2-3) Purpura/Echymoses (range 1-3) Dryness Teleangiectasia (range 2-3) (range 1-2) Table 3.
Mean epidermal and dermal thickness, skin elasticity, erythemal and moisture indexes at baseline and after 8 months of treatment with Vivida of 40 patients with corticosteroid induced skin atrophy. Parameters Baseline 8 months Epidermal thickness (mm) (-) (-) Dermal thickness (mm) (-) (-) Elasticity Index 44 (39-53) 74 (65-78) Erythemal Index (-) (-) Moisture Index (11-37) (75-97)