Side-effects from the use of steroids are extremely common and can be quite significant. Most side-effects are reversible once the athlete stops usage although serious long-term side-effects and even death have occurred as a direct result of steroid use.
• Decreased sperm production and sex drive
• Increased aggression, irritability and mood swings
• Liver disorders
• Baldness (alopecia)
• Hypertension (high blood pressure)
• Raised cholesterol
• Gynecomastia (development of over-sized mammary glands in males)
• Menstrual irregularities (in women)
• Hirsuitism (excessive hair growth occurring in females which follows the pattern of male hair growth, . facial)
• Deepening of the voice
• Reduced immunity
• Possible development of tumors (wilm’s tumor, prostate carcinoma and leukemia have been reported, although a connection is not proven)
The National Heart, Lung, and Blood Institute (NHLBI) recommended dosing for systemic prednisone, prednisolone, or methylprednisolone in pediatric patients whose asthma is uncontrolled by inhaled corticosteroids and long-acting bronchodilators is 1–2 mg/kg/day in single or divided doses. It is further recommended that short course, or "burst" therapy, be continued until the patient achieves a peak expiratory flow rate of 80% of his or her personal best or until symptoms resolve. This usually requires 3 to 10 days of treatment, although it can take longer. There is no evidence that tapering the dose after improvement will prevent a relapse.