The G α subunit will eventually hydrolyze the attached GTP to GDP by its inherent enzymatic activity, allowing it to re-associate with G βγ and starting a new cycle. A group of proteins called Regulator of G protein signalling (RGSs), act as GTPase-activating proteins (GAPs), are specific for G α subunits. These proteins accelerate the hydrolysis of GTP to GDP, thus terminating the transduced signal. In some cases, the effector itself may possess intrinsic GAP activity, which then can help deactivate the pathway. This is true in the case of phospholipase C -beta, which possesses GAP activity within its C-terminal region. This is an alternate form of regulation for the G α subunit. Such G α GAPs do not have catalytic residues (specific amino acid sequences) to activate the G α protein. They work instead by lowering the required activation energy for the reaction to take place. 
Richard Pound , chairman of the World Anti-Doping Agency and a partner in the Canadian law firm Stikeman Elliott, says: "The use of performance-enhancing drugs is not accidental; it is planned and deliberate with the sole objective of getting an unfair advantage. I don't want my kids, or your kids, or anybody's kids to have to turn themselves into chemical stockpiles just because there are cheaters out there who don't care what they promised when they started to participate. I don't want my kids in the hands of a coach who would encourage, condone or allow the use of drugs among his or her athletes."