Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.
_____ 25. Your patient is receiving a protocol that includes
both Adriamycin and Cytoxan. You notice a redness in the urine.
You conclude that
a. there must be a UTI and the patient needs a sulfa drug
b. the redness is definitely blood since Adriamycin is known to cause hemorrhagic cystitis
c. the redness is possibly, but not necessarily, indicative of the presence of blood in this case
d. extravasation has occurred and protective measures are necessary