Without the C17-aa nature, most oral steroid pills would be useless, but the obvious question is while they carry a toxic nature, how toxic is it? Different steroid pills carry varying levels of toxicity, for example, Halotestin is the most toxic of all C17-aa steroids, while Anavar is very mild. Of course, total dosing and duration of use will play a role, but on a per pill basis, most steroid pills are not as damaging to the liver as excessive alcohol consumption, and not nearly as toxic as many over the counter medications. Even so, unlike most over the counter medications, because steroid pills are taken every day when they are being used this presents a higher level of toxicity to the liver. When you supplement with oral steroids, your liver enzyme levels will increase, and this is assured. However, for the healthy adult male who does not add any additional stress to his liver, who lives a healthy lifestyle and supplements responsibly, once use is discontinued his enzyme levels will return to normal. The liver has remarkable rejuvenating capabilities, and with responsible use, permanent damage can in most all cases be avoided.