Based on the one-on-one interactions Butters and Jimmy have had on the show, they seem to be good friends. In " Krazy Kripples ," Butters was the only person who went to see Jimmy's comedy show instead of Christopher Reeve's public appearance. In " Erection Day ," Jimmy came to Butters for advice on his erection problems, expressing that Butters is the only one he can tell who won't make fun of him for it. The two were also seen sitting together at Cartman's AIDS benefit in " Tonsil Trouble ". During Season Fifteen's episode " 1% " Jimmy and Butters form the 99% club to protest the Presidential Fitness Test results. They stand outside and picket the President's Council on Fitness, Sports & Nutrition, Colorado Division Regional Office, only the media believe they are protesting the Red Robin Restaurant. In " Funnybot ," Butters is the only person in the audience who was clapping and cheering Jimmy while everybody else was asleep. In " Going Native ," Butters reveals that he doesn't find Jimmy's jokes funny. In " A Nightmare on Face Time ," the two are seen trick-or-treating together.
In the Season 19 episode " Tweek x Craig ", Asian-American female students started drawing homoerotic " yaoi " images of Craig and Tweek depicting them as lovers. Immediately, the two try to repudiate the rumors about them prompted by this. They eventually resolve to stage a public "break-up" to end the rumors. Though Tweek fears he cannot do this believably, Craig encourages him that he indeed can. However, Tweek goes too far by claiming that Craig is a manipulative cheater, which has the effect of ruining Craig's reputation with girls. Tweek later reveals that Craig's encouragement him gave him the confidence to believe in himself. Following the father-to-son talk between him and his father about how “you can’t fight being gay”, the two boys have been engaged in a relationship, at the time seemingly just to appease the townspeople, however in later productions such as the season 21 episode " Put It Down " and The Fractured But Whole , they are shown through their continuous treatment of each other as romantic partners even in private settings to be a real couple.
Liane Marie Cartman , originally voiced by Mary Kay Bergman and later by Eliza J. Schneider and April Stewart , is the generally sweet-natured mother of Eric Cartman ; though in later seasons, she has been shown to be a more proactive mother who does not tolerate his antics or foul language. Her promiscuity , often with total strangers, was a running gag initially. It seemed as though all of the adults in South Park had slept with her (including the women). Although in episode 7, she is indicated to be a " crack whore ", she says in " The Poor Kid " that she has not done drugs in some time, and works two jobs, even though she and Eric are the second poorest family in South Park (at least of those whose children attend South Park Elementary) after Kenny McCormick 's.  It is first revealed that she is a hermaphrodite (and so is Eric's father), though in episode " 201 " it is revealed that Eric's real father is Jack Tenorman , the father of his nemesis Scott Tenorman a member of the 1991 Denver Broncos, and the ruse about her being a hermaphrodite was made up to maintain the Broncos’ reputation since “they were having a good year”