Intranasal corticosteroid potency

The precise mechanism through which fluticasone propionate affects rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. In 7 trials in adults, fluticasone propionate nasal spray has decreased nasal mucosal eosinophils in 66% of patients (35% for placebo) and basophils in 39% of patients (28% for placebo). The direct relationship of these findings to long-term symptom relief is not known.

LABA+ICS群と比較し、LAMA+LABA群の統合された主要評価項目の結果は以下の通りである:増悪、OR (95%CI ~、P = 、I 2 = 17%、低い質のエビデンス);重篤な副作用、(95%CI ~、P = 、I 2 = 0%、中等度の質のエビデンス);St. George's Respiratory Questionnaire (SGRQ)ベースラインからの変化、MD -(95%CI ~、P = 、I 2 = 71%、低い質のエビデンス);トラフ一秒量ベースラインからの変化、MD (95%CI ~、P <、I 2 = 50%、中程度の質のエビデンス)。同様に二次評価項目の結果は以下の通りである:肺炎、OR (95%CI ~、P = 、I 2 = 0%、低い質のエビデンス);全死亡、OR (95%CI ~、P = 、I 2 = 0%、低い質のエビデンス)、臨床的有意な最小変化量(4点)以上のSGRQベースラインからの改善、OR (95%CI ~、P = 、I 2 = 0%、中等度の質のエビデンス)。

Intranasal corticosteroid potency

intranasal corticosteroid potency

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