Aspirin acts by inhibiting the production of prostaglandins , body chemicals that are necessary for blood clotting and are noted for sensitizing nerve endings to pain . The use of aspirin has been known to cause allergic reaction and gastrointestinal problems in some people. It has also been linked to the development in children (primarily those 2 to 16 years old) of Reye syndrome , an acute disorder of the liver and central nervous system that may follow viral infections such as influenza and chicken pox , and to the development of age-related macular degeneration (a blinding disorder) in some persons who use the drug regularly over many years. Like almost all drugs, aspirin is to be avoided during pregnancy. Compare acetaminophen ; ibuprofen .
After percutaneous coronary interventions (PCIs), such as the placement of a coronary artery stent , a . Agency for Healthcare Research and Quality guideline recommends that aspirin be taken indefinitely.  Frequently, aspirin is combined with an ADP receptor inhibitor , such as clopidogrel , prasugrel , or ticagrelor to prevent blood clots . This is called dual antiplatelet therapy (DAPT). United States and European Union guidelines disagree somewhat about how long, and for what indications this combined therapy should be continued after surgery. guidelines recommend DAPT for at least 12 months, while EU guidelines recommend DAPT for 6–12 months after a drug-eluting stent placement.  However, they agree that aspirin be continued indefinitely after DAPT is complete.
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