Anabolic hormones in the body

The hormones obtained from extracts of the endocrine glands may be classified into four groups according to their chemical constitution: (1) phenol derivatives, such as epinephrine, norepinephrine, thyroxine, and triiodothyronine; (2) proteins, such as the anterior pituitary hormones, with the exception of adrenocorticotropic hormone (ACTH), human chorionic gonadotropin, pregnant-mare-serum gonadotropin, and thyroglobulin; (3) peptides, such as insulin, glucagon, ACTH, vasopressin, oxytocin, and secretin; and (4) steroids, such as estrogens, androgens, progesterone, and corticoids. Hormones, with a few exceptions like pituitary growth hormone and insulin, may also be classified as either tropic hormones or target-organ hormones. The former work indirectly through the organs or glands which they stimulate, whereas the latter exert a direct effect on peripheral tissues. See Endocrine system (vertebrate)

Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was ± (years ± SD, age range -). After adjusting for age, magnesium was positively associated with total testosterone (β ± SE, ± ; p = ) and with total IGF-1 (β ± SE, ± ; p = ). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β ± SE, ± ; p = ). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β ± SE, ± ; p = ) and remained significant after adjusting for total testosterone (β ± SE, ± ; p = ). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.

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Anabolic hormones in the body

anabolic hormones in the body

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